Ketoconazole 2%
Mechanism of action
1. Inhibition of Ergosterol Synthesis
Ketoconazole inhibits the fungal enzyme cytochrome P450–dependent lanosterol 14-α-demethylase (CYP51).
This enzyme converts lanosterol → ergosterol, which is an essential structural component of fungal cell membranes
Loss of membrane integrity → impaired fungal growth.
2. Fungistatic and Fungicidal Activity
At lower concentrations: fungistatic (inhibits fungal growth).
At higher concentrations: fungicidal (kills fungal cells).
3. Anti-inflammatory Effect on Skin

Benefits of Ketoconazole Soap
1.Broad-spectrum antifungal activity
Effective against dermatophytes (Trichophyton, Microsporum), yeasts (Candida), and Malassezia species.
2.Treatment of superficial fungal infections
Tinea corporis
Tinea cruris
Tinea versicolor
Cutaneous candidiasis
3.Prevents recurrence of fungal infections
4.Improves skin hygiene in fungal-prone areas
5.Useful in humid climates and sweat-prone areas.