1. Minoxidil (Topical)
Mechanism of Action
1. Potassium Channel Opening
• Minoxidil is converted in the scalp to minoxidil sulfate by sulfotransferase enzymes.
• The active metabolite opens ATP-sensitive potassium channels in dermal papilla cells.
• This hyperpolarizes the cell membrane and stimulates hair follicle activity.
2. Vasodilation and Increased Blood Supply
3. Prolongation of Anagen Phase
• Shortens telogen phase and stimulates transition of dormant follicles into anagen (growth phase).Leads to increased hair length and thickness.
4. Up-regulation of Growth Factors
• Stimulates VEGF (Vascular Endothelial Growth Factor) expression in dermal papilla.
• Promotes angiogenesis and follicular nourishment.
5. Activation of Wnt/β-catenin Signaling
• Enhances follicular cell proliferation and differentiation.
• Stimulates conversion of vellus hair → terminal hair.

2. Finasteride (Topical)
Mechanism of Action
1. Inhibition of Type II 5-Alpha Reductase
• Prevents conversion of testosterone → dihydrotestosterone (DHT).
2. Reduction of Follicular DHT
• Lower DHT reduces androgen-mediated miniaturization of hair follicles.
3. Reversal of Follicular Miniaturization
• Allows recovery of dermal papilla cells and promotes thicker terminal hair growth.
4. Prolongation of Anagen Phase
• Reduced androgen signaling prolongs the growth phase of the hair cycle.

Key Benefits:-
1. Dual-Action Anti-Hair Loss Therapy target the primary cause of androgenetic alopecia
2. Clinically Proven Hair Regrowth
Promotes reactivation of dormant follicles and stimulates new terminal hair growth.
3. Reduces DHT-Induced Follicle Miniaturization
4. Enhances Hair Density and Thickness
5. Prolongs the Hair Growth (Anagen) Phase
Supports longer and stronger hair growth cycles while reducing premature hair shedding.
6. Improves Scalp Microcirculation
Minoxidil enhances blood flow and nutrient delivery to the hair follicle for optimal follicular function.
7. Comprehensive Management of androgenetic Alopecia